Clinical significance of elevated B-type natriuretic peptide in patients with ...
The primary objective of this study was to examine levels of B-type natriuretic peptide (BNP) in mechanically ventilated patients with acute lung injury and to test whether the level of BNP would be higher in patients with right ventricular dilatation and would predict mortality.Methods: Prospective observational cohort study of 42 patients conducted in the intensive care unit of a tertiary care university hospital. BNP was measured and transthoracic echocardiography was performed within 48 hours of the onset of acute lung injury.
The left ventricular systolic and diastolic function, right ventricular systolic function and cardiac output were assessed. BNP was compared in patients with and without right ventricular dilatation, as well as in survivors versus nonsurvivors.
Results: BNP was elevated in mechanically ventilated patients with acute lung injury (median 420 pg/ml, 25-75% IQR 156-728 pg/ml).
There was no difference between patients with and without right ventricular dilatation (420 pg/ml, 119-858 pg/ml versus 387 pg/ml, 156-725 pg/ml, p=0.96). There was no difference in BNP levels between the patients who died and those who survived at 30 days (420 pg/ml, 120-728 pg/ml versus 385 pg/ml, 159-1070 pg/ml, p=0.71).
Conclusions: In patients with acute lung injury the level of BNP is increased but there is no difference in the BNP level between patients with and without right ventricular dilatation.
Furthermore, BNP level is not predictive of mortality in this population.
B-type Natriuretic Peptide - News
As described by Marcus 2 in his insightful commentary on this study, several clinical characteristics including family history of AF and B-type natriuretic peptide levels (which have been shown to improve risk stratification for the prediction of AF
The primary objective of this study was to examine levels of B-type natriuretic peptide (BNP) in mechanically ventilated patients with acute lung injury and to test whether the level of BNP would be higher in patients with right ventricular dilatation
Brain (or B-type) natriuretic peptide (BNP) is enzymatically cleaved from a larger precursor protein, leaving the N-terminal end -- NT-proBNP -- as a waste product. In recent years, it has been found to be an accurate marker for heart failure.
The study, published online in the June 20 edition of the journal Heart, put 25 men and five women (average age 39) through a comprehensive lab, clinical and instrumental assessment, including B-type natriuretic peptide and troponin I assay,
The participants (25 men and five women, with an average age of 39 years) underwent a thorough cardiac investigation, including echocardiography, B-type natriuretic peptide and troponin I assay, exercise stress test, 24-hour echocardiogram (ECG)
B-Type Natriuretic Peptide Signal Peptide Circulates in Human ...
From the Christchurch Cardioendocrine Research Group, University of Otago, Christchurch (M.S., V.A.C., T.G.Y., M.G.N., A.M.R., C.J.P.); Centre for Protein Research, Department of Biochemistry, University of Otago, Dunedin (T.K.); and Green Lane Cardiovascular Service, Auckland City Hospital, Auckland (P.R.), New Zealand.
Correspondence to Dr Chris J. Pemberton, Christchurch Cardioendocrine Research Group, Department of Medicine, University of Otago, Christchurch, PO Box 4345, Christchurch 8140, New Zealand.
B-type Natriuretic Peptide - Bookshelf
Congestive heart failure
Obesity and suppressed B- type natriuretic peptide levels in heart failure. ... Bedside B-type natriuretic peptide in the emergency diagnosis of heart ...Intensive Care Medicine, Annual Update 2010
Coquet I, Darmon M, Doise JM, et al (2008) Performance of N-terminal-pro-B-type natriuretic peptide in critically ill patients: a prospective observational ...Evidence-Based Cardiology
B-TYPE NATRIURETIC PEPTIDE 95. de Lemos JA, et al. The prognostic value of B- type natriuretic peptide in patients with acute coronary syndromes. ...Stability of B-type natriuretic peptide levels during exercise in patients with congestive heart failure, implications for outpatient monitoring with B-type natriuretic peptide
Yearbook of Intensive Care and Emergency Medicine
33 II B-Type Natriuretic Peptide: An Emerging Biomarker in Pediatric Critical Care PE Oishi, J.-H. Hsu, and JR Fineman Introduction In 1988, ...Casual Knowledge Directory
Brain natriuretic peptide - Wikipedia, the free encyclopedia
Brain natriuretic peptide (BNP), now known as B-type natriuretic peptide (also ... B-type natriuretic peptide (BNP) levels and ethnic disparities in ...
B-type Natriuretic Peptide (BNP) blood test
heart failure diagnosis - Heart & Vascular is a leader in cardiovascular disease treatment with top heart disease physicians, and experts in heart failure care and ...
B-type natriuretic peptide definition - Medical Dictionary ...
B-type natriuretic peptide: A 32-amino-acid polypeptide secreted by the ventricles of the ... The levels of B-type natriuretic peptide (BNP) are elevated in ...
B-Type Natriuretic Peptide
B-type natriuretic peptide (BNP) is a neuro- hormone released from the ventricles of the ... Figure 1. Levels of B-type natriuretic peptide (BNP) on day 0 for ...
B-Type Natriuretic Peptide
Can measuring B-type natriuretic peptide levels help physicians guide therapy for the management of heart failure?